The 2025 Israeli MR Annual Meeting held in memory of

Prof. Asher Schmidt

The Israeli Annual Magnetic Resonance Meeting in Memory of Prof. Asher Schmidt

Israel’s NMR community recently gathered at The Israeli 2024 Magnetic Resonance Meeting, which recently took place at the Technion. The event was dedicated to the memory of Prof. Asher Schmidt, one of Israel's leading solid-state NMR scientists, who passed away unexpectedly a year ago. The Technion had been his academic home for over 25 years

The day-long symposium was initiated and sponsored by the Institute of Advanced Studies in Theoretical Chemistry (IASTC) at the Technion. One of the Institute's goals is to organize and support meetings that foster collaboration between theoreticians and experimentalists. Additional support was provided by Bruker and Prof. Efrat Lifshitz, Dean of the Schulich Faculty of Chemistry at the Technion. The meeting was organized by Prof. Aharon Blank and Dr. Shifi Kababya

Israel’s Magnetic Resonance community is a tight-knit family of scientists who are leaders in this field on a global level. Prof. Schmidt had been an active member of the community for decades, having pioneered sophisticated solid-state nuclear magnetic resonance (NMR) strategies. Together with the late Prof. Shimon Vega from the Weizmann Institute of Science, Prof. Schmidt utilized Floquet theory to explain novel phenomena they discovered in solid-state NMR. At the IASTC, Floquet theory has been further extended to address atomic and molecular systems with finite lifetimes, driven by their interactions with strong lasers

In his opening remarks at the symposium, Prof. Nimrod Moiseyev, head of the IASTC, emphasized the passion for Floquet theory shared by Asher Schmidt, Shimon Vega, and himself. This shared interest enabled them to explore and uncover new phenomena in nature

The day’s lecturers and attendees came from all of Israel’s major universities, with an especially large contingent from the Weizmann Institute, as well as several guests from abroad and a handful from industry. Many of the speakers had been Prof. Schmidt’s colleagues or students, and even those who hadn’t known him personally paid homage to his legacy

Remembering a beloved scientist

Prof. Schmidt served as the Head of the Division of Physical and Analytical Chemistry in the Schulich Faculty of Chemistry and headed the Chemistry Research Center. For more than two decades, his work focused on fine and intricate molecular-level details of complex functional materials such as biominerals, enzyme active sites, and surface sites where binding-adsorption-catalysis occur. To achieve physicochemical insights on these complex systems, he devised and applied sophisticated solid-state NMR strategies that made it possible to characterize the molecular-chemical entities and unravel the underlying mechanisms as they work in situ

Schmidt was born in Tel Aviv in 1955 and received a B.Sc. from The Hebrew University of Jerusalem, followed by an M.Sc. from The Weizmann Institute of Science in the theoretical department, under the supervisor of Prof. Itamar Procaccia, and then a Ph.D. at Weizmann under the renowned NMR pioneer Prof. Shimon Vega. He then conducted postdoc research at Washington University in St. Louis, and in 1993 became an Assistant Professor in the Department of Physics at the University of Connecticut. In 1997, he returned to Israel as a faculty member at the Technion. He was also a Visiting Professor at Washington University and at the Sorbonne Université in Paris

During his final decade, Prof. Schmidt concentrated on biominerals and biomimetic minerals. Biomineralization is the process by which organisms produce composite inorganic-organic materials with exceptional microscopic, morphologic, and mechanical qualities. Using modern solid-state NMR spectroscopy techniques, Prof. Schmidt could focus on molecular interactions within biominerals and determine their molecular-level structures. In particular, he studied calcium carbonate biomineralization systems such as plankton coccolith (E. Hux), gastroliths of blue crayfish, different types of shells and many other model systems to understand the nature formation of CaCO3

In addition to his outstanding scientific career, Prof. Schmidt’s equally remarkable personality resonated throughout the day. In his opening remarks, Prof. Nimrod Moiseyev told the audience about how, every morning, he would knock on the door of Prof. Schmidt’s office, which was next to his own office, and how they would discuss not only their work but also personal and political matters. Prof. Moiseyev and all the other speakers who knew Prof. Schmidt described an exceptionally friendly, modest and kindhearted person who always had a smile on his face and was an inspiration to everyone he knew

Prof. Schmidt’s close family members attended the symposium, including his wife Tzukit and their two children. Friends, colleagues and family members joined the event via Zoom

Rich program of interesting lectures

The day consisted of back-to-back talks covering a wide range of topics related to the field of magnetic resonance. Dr. Ira Ben Shir, who was Prof. Schmidt’s doctoral student and co-worker for 15 years, gave a lecture that celebrated her mentor’s contribution to molecular insights into biomineralization using solid-state NMR. She described Prof. Schmidt’s most recent work and outlined his legacy: “Solid-state NMR is a unique source of molecular-level insight on the origin of macroscopic properties and function. Its combination with other spectroscopic, microscopic, structural and computational methods is key to advancing both the fundamental and technological aspects.”

Prof. Lucio Frydman of the Weizmann Institute of Science gave an especially relevant and thought-provoking talk entitled “Can NMR Spectroscopy be of Help for Preventing Deaths from Pancreatic Cancer?” Since Prof. Schmidt died of pancreatic cancer and the two scientists had been friends for many years, this lecture combined scientific and personal perspectives. Prof. Frydman explained about his research on altered glucose which, when digested by cancer cells, helps reveal tumors’ hiding places. Since pancreatic tumors are especially difficult to detect, resulting in grim prognoses for patients, this research could potentially help diagnose people like Prof. Schmidt at much earlier stages, in time to administer life-saving treatment. The new MRI approach tracks how cells metabolize glucose of aggressive pancreatic cancer in rodent models, using a chemically altered glucose containing a stable isotope of hydrogen called deuterium. Although these findings need to be confirmed in human patients, Frydman believes that deuterium MRI offers a new horizon for improved early detection of pancreatic cancer

Other interesting talks included Prof. Yishay Manassen of Ben-Gurion University of the Negev on “Scanning Tunnelling Microscope NMR,” which can be used to discover even a single molecule on a biopsy surface and thereby identify cancer; Dr. Moti Freiman of the Technion’s Faculty of Biomedical Engineering on “Model-Based Self-Supervised Motion Correction for Robust Cardiac T. Mapping;” and Dr. Or Perlman of Tel Aviv University on “AI-Based Interventions Along the Molecular MRI Pipeline: The Quest for Speed, Specificity, and Histological Fidelity,” among others. Prof. Dr. Eike Brunner of TU Dresden delivered his lecture on “Solid-State NMR Investigations of Silica Biomineralization in Diatoms” via Zoom

The symposium also included a lecture by one of Asher Schmidt’s close personal friends, Dr. Roni King, a former veterinarian of the Israel Nature & Parks Authority. He spoke about efforts to contain rabies in Israel, especially through oral vaccinations of wildlife. In addition, the Schulich Faculty of Chemistry’s biweekly faculty colloquium took place during the afternoon session: Prof. Amir Goldbourt of Tel Aviv University gave a talk titled “Dynamics Averaging of Anisotropic NMR Interactions Reveal Different Dynamic Behavior in Filamentous Phage Capsids.”

All in all, the symposium successfully combined professional and personal elements. The event offered a well-organized, rich program that showcased all the latest research of interest to Israel’s community of magnetic resonance scientists, while at the same time paying homage to an important member of that community in a manner that honored his memory